Opioid peptides.

Opioid peptides.

Opioid Peptides: Medicinal Chemistry, 69

Opioid peptides and pituitary function.

A number of in-vitro model systems have been introduced for the study of the action of morphine-like drugs. Their usefulness depends on their relative simplicity, compared to the brain and central nervous system, and on the good correlation observed between potencies in the models and potencies in the whole animal. For example, the contractions of the isolated guinea\x=req-\ pig ileum and mouse...

Non-opioid peptides for analgesia.

Amongst the spinal peptide candidates believed to be involved in the mediation of analgesia, only somatostatin fulfills the criterium of a real analgesia substance. Spinal somatostatin specifically blocks the transmission of painful stimuli. Spinal calcitonin may lower the opioid dose requirement in patients with bone metastases but it fails to relieve acute pain. The usefulness of ACTH and CRF...

Opioid Peptides: An Update, 87

Possible involvementofendogenousopioids inhumoral immune responseshas been explored in the experimental animals. Opioid agonists likemorphine and leu-enkephalin significantly enhanced antigen-inducedhistamine release from the peritoneal mast cells of sensitised rats invitro; this was effectively antagonised by naloxone. Naloxone itselfinhibited antigen-induced histamine rele...